Melan A

IFU

Description: Melan-A is a melanoma-specific antigen on neoplastic melanocytes that is recognized by cytotoxic T lymphocytes¹. Melan-A is expressed in skin and in many melanocytes. Antibodies labeling Melan-A have been shown to be useful for labeling melanomas and other tumors showing melanocytic differentiation while not staining tumor cells of epithelial, lymphoid, glial, or mesenchymal origin^2,3. 

Catalog: VMAB003

Clone: CHMP008

Species Reactivity: Dog

Source: Recombinant Rabbit Monoclonal

Isotype: IgG

Antigen: Recombinant full-length human MART-1 protein

Cellular Location: Cytoplasmic

Positive Control: Melanoma

References:

1. Ohsie, S.J., Sarantopoulos, G.P., Cochran, A.J., and Binder, S.W. Immunohistochemical characteristics of melanoma. J Cutan Pathol. 2008;35(5):433-444. [PMID: 18399807]
2. Ramos-Vara J.A., Beissenherz, M.E., Miller M.A., et al. Retrospective study of 338 canine oral melanomas with clinical, histologic, and immunohistochemical review of 129 cases. Vet Pathol. 2000;37(6):597-608. [PMID: 11105949]
3. Koening, A., Wojcieszyn, J., Weeks, B.R., Modiano, J.F. Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cell lines and twenty-nine retrospective cases of canine melanoma. Vet Pathol. 2001;38(4):425-435. [PMID: 11467477]

Bioinformatics

Entrez Gene ID: 2315
Gene Symbol: MLANA
SwissProt: Q16655