Description: This monoclonal antibody recognizes desmin, which is an intermediate filament protein, and labels cells of normal smooth, skeletal, and cardiac muscles. The antibody does not cross-react with other intermediate filament proteins.
This marker has been shown to be useful for identifying tumors of myogenic origin including leiomyosarcomas and rhabdomyosarcomas.
Catalog: VMABXXX
Clone:
Species Reactivity: Cat and Dog
Source: Mouse Monoclonal
Isotype: IgG
Antigen: Recombinant full-length human DES protein
Cellular Location: Cytoplasmic
Positive Control: Leiomyosarcoma and uterus
References:
- Andreasen, C.B., and Mahaffey, E.A. Immunohistochemical demonstration of desmin in canine smooth muscle tumors. Vet Pathol. 1987;24(3):211-215. [PMID: 3300003]
- LaRock, R.G., and Ginn, P.E. Immunohistochemical stainign characteristics of canine gastrointestinal stromal tumors. Vet Pathol. 1997;34(4):303-311. [PMID: 9240839]
- Martin-Mulas, J., Vos, J.H., and Van Mil, F.N. Desmin and Vimentin Immunocharacterization of Feline Muscle Tumors. Vet Pathol. 1992;29(3):260-262. [PMID: 1621338]
Bioinformatics:
Entrez Gene ID: 1674
Gene Symbol: DES
SwissProt: P17661